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bioavailability

American  
[bahy-oh-uh-vey-luh-bil-i-tee] / ˌbaɪ oʊ əˌveɪ ləˈbɪl ɪ ti /

noun

Biochemistry.
  1. the extent to which a nutrient or medication can be used by the body.


bioavailability British  
/ ˌbaɪəʊəˌveɪləˈbɪlɪtɪ /

noun

  1. Also called: systemic availability.  the extent to which a drug or other substance is taken up by a specific tissue or organ after administration; the proportion of the dose of a drug that reaches the systemic circulation intact after administration by a route other than intravenous

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

  • bioavailable adjective

Etymology

Origin of bioavailability

First recorded in 1965–70; bio- + available ( def. )

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

“Systemic therapies have shown poor bioavailability in pancreatic tumors, limiting their effectiveness. Optune Pax is a fundamentally different treatment, utilizing a biophysical approach that targets the unique electrical properties of cancer cells.”

From Barron's

This low bioavailability raises an important question: if so little is absorbed, how do flavanols still appear to influence brain function and the nervous system?

From Science Daily

"Stress responses elicited by flavanols in this study are similar to those elicited by physical exercise. Thus, moderate intake of flavanols, despite their poor bioavailability, can improve the health and quality of life," remarks Dr. Fujii.

From Science Daily

"By contrast, small-molecule drugs that are designed to cross the blood-brain barrier are hydrophobic in nature, which limits their bioavailability, increases the risk of off-target binding, and is linked to side effects."

From Science Daily

Of the many carotenoids found in nature, beta-carotene is the star player: a strong orange tint and high "bioavailability" — the term used to describe drug absorption — make it particularly influential.

From Salon